Skin penetration enhancement using free base and acid addition salt combinations of active agents
US4888354A · kind A · utility
103Cited by
5References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 21, 1987 |
| Grant date | Dec 19, 1989 |
| Priority date | — |
| Expiry date | Dec 21, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/22
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention is directed to compositions for topical application made up of active pharmaceutical permeants capable of existing in both free base and acid addition salt form. The permeants are present as a combination of both free base and acid addition salt forms. These combined forms provide skin penetration rates which are greater than the penetration rate of either the free base or acid addition salt forms utilized separately. The combined free base-acid addition salt permeants are formulated in a carrier vehicle which preferably also possesses skin penetration enhancement activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.