Gelonin immunotoxin
US4888415A · kind A · utility
31Cited by
5References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 7, 1988 |
| Grant date | Dec 19, 1989 |
| Priority date | — |
| Expiry date | Mar 7, 2008 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/828
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Immunotoxins having improved toxic activity have the composition ##STR1## wherein Toxin-NH is a ribosome-inactivating protein containing no accessible sulfhydryl groups, n is an integer from 1 to 5, m is an integer from 1 to 5, and NH-Antibody is a monoclonal antibody specific to eucaryotic cells or antigens associated therewith. The immunotoxins are made by reacting the Toxin-NH with an iminothiolester salt to form a first conjugate, reacting the NH-Antibody with N-succinimidyl-3-(2-pyridyldithio) propionate to form a second conjugate, and reacting the two conjugates to form the immunotoxin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.