Bioreactor apparatus
US4889812A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 12, 1986 |
| Grant date | Dec 26, 1989 |
| Priority date | — |
| Expiry date | May 12, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/813
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A novel class of bioreactor apparatuses are disclosed which offer improved performance over prior art designs. The apparatuses circulate nutrient fluid through a bioreactor device, such as a hollow fiber bioreactor cartridge, which is used to culture a colony of cells. The nutrient fluid is refreshed by the controlled addition of fresh fluid and the controlled removal of used fluid through a sterile infusion/extraction device. Cellular by-product yield is enhanced by periodically alternating the direction of nutrient fluid through the bioreactor and by periodically circulating the harvest fluid through the extracapillary region of the bioreactor cartridge.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.