Steroidal liposomes

US4891208A · kind A · utility

Assignee

• The Liposome Company, Inc. · US

Inventors

• Andrew S. Janoff · Yardley, US
• Mircea C. Popescu · Plainsboro, US
• Alan L. Weiner · Lawrenceville, US
• Lois E. Bolscak · Lawrenceville, US
• Paul A. Tremblay · Princeton, US
• Christine E. Swenson · Princeton, US

Key dates

• Filing date: Sep 10, 1985
• Grant date: Jan 2, 1990
• Expiry date: Sep 10, 2005

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2984
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Steroidal liposomes comprising a bioactive agent and method for their administration are disclosed, the bilayers of said steroidal liposomes comprising a salt form of a carboxylic acid derivative of a sterol, a salt form of a polycarboxylic acid derivative of a sterol, a salt form of a hydroxy carboxylic acid derivative of a sterol, a salt form of an amino acid derivative of a sterol or a salt form of a poly (amino acid) derivative of a sterol; or a salt form of an organic acid derivative of cholesterol, a vitamin D, a phytosterol, or a steroidal hormone.