Bioerodible polyanhydrides for controlled drug delivery
US4891225A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 21, 1986 |
| Grant date | Jan 2, 1990 |
| Priority date | — |
| Expiry date | Jan 21, 2006 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L27/58
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A novel hydrophobic polymeric matrix is provided which is suitable for use after implantation in vivo in a subject for the controlled release and delivery of biologically active substances such as drugs, antibiotics, steroids and the like. Alternatively, the matrix can be used outside the body for release of fragrances, pesticides and the like. The implantable matrix comprises a polymeric polyanhydride formulation whose internal anhydride linkages are hydrolytic in nature in varying degrees in accordance with the chemical composition of the backbone, pH and temperature of the environment. As the individual anhydride linkages become hydrolyzed, the matrix erodes predominantly by surface erosion into non-toxic biocompatible degradation products with concomitant release of the biologically active substance.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.