Method of controlling culture
US4891310A · kind A · utility
7Cited by
3References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 25, 1986 |
| Grant date | Jan 2, 1990 |
| Priority date | — |
| Expiry date | Mar 25, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/61
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method of controlling culture wherein cells are aerobically cultured to produce metabolite is characterized by adding substrate and/or inducer to the culture broth, judging the endpoint of the growth of the cells and/or the production of the metabolite or terminating the culture under the guidance of a change in the ratio of the first parameter based on the amount of carbon dioxide evolved by the cell culture to the second parameter based on the amount of oxygen consumed by the cell culture. The ratio is a respiratory quotient, for instance.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.