3-(Acylaminomethyl)imidazo[1,2-a]pyridine derivatives, their preparation and their application in therapy

US4891371A · kind A · utility

Assignee

• Synthelabo · FR

Inventors

• Pascal George · Rambouillet, FR
• Claudie Giron · Antony, FR
• Jacques Froissant · Châteaudun, FR

Key dates

• Filing date: Jun 10, 1988
• Grant date: Jan 2, 1990
• Expiry date: Jun 10, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound which is a 3-(acylaminomethyl)imidazo[1,2-a]pyridine derivative of formula (I) ##STR1## in which R.sub.1 denotes hydrogen; linear or branched C.sub.1 -C.sub.4 alkyl; or benzyl: PA1 R.sub.2 denotes linear or branched C.sub.1 -C.sub.6 alkyl; cyclohexyl; trichloromethyl; 1-propenyl; allyl; phenyl; 4-chlorophenyl; or benzyl; or R.sub.1 and R.sub.2 together denote a C.sub.3 -C.sub.5 aliphatic chain: PA1 X denotes halogen; C.sub.1 -C.sub.3 alkyl; methylthio; trifluoromethyl; optionally esterified carboxy of formula --COOR in which R denotes hydrogen or C.sub.1 -C.sub.6 alkyl; cyano; optionally mono- or dialkylated aminocarbonyl of formula --CONR.sub.3 R.sub.4 in which R.sub.3 and R.sub.4 independently denote hydrogen or C.sub.1 -C.sub.4 alkyl or together denote a chain of formula --(CH.sub.2).sub.2 --Z--(CH.sub.2).sub.2 -- in which Z denotes a direct bond, oxygen, sulphur, or a divalent group of formula --CH.sub.2 --, --NH--or --N(C.sub.1 -C.sub.4 alkyl)--; alkylamino of formula NHR.sub.5 in which R.sub.5 denotes C.sub.2 -C.sub.6 alkyl; or dialkylamino of formula --NR.sub.6 R.sub.7 in which R.sub.6 R.sub.7 independently denote C.sub.2 -C.sub.6 alkyl or together denote a chain …