Imidazo- and triazolothiadiazines

US4891374A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Werner Thorwart · Hochheim, DE
• Ulrich Gebert · Königstein, DE
• Rudolf Schleyerbach · Hofheim, DE
• Robert R. Bartlett · Darmstadt, DE

Key dates

• Filing date: Jan 28, 1988
• Grant date: Jan 2, 1990
• Expiry date: Jan 28, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D233/86
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel imidazo- and triazolothiadiazines of the general formula I ##STR1## in which R.sup.1 =C.sub.1 -C.sub.4 -alkyl, PA0 R.sup.2 =H or C.sub.1 -C.sub.3 -alkyl PA0 and the structural element --A--B--=--CH.sub.2 --CH.sub.2 --, --CH CH--, --CH.dbd.N--, --CH.sub.2 --CO-- or --CO--CH.sub.2 --, and the physiologically aceptable acid-addition salts thereof, are prepared by reacting 2-halo-1-phenylalkanones of the formula II ##STR2## (meaning of R.sup.1 and R.sup.2 as in formula I, X=halogen) with compounds of the formula III ##STR3## (meaning of --A--B-- as in formula I) and, if appropriate, converting the compounds of the formula I formed into the physiologically acceptable acid-addition salts thereof by means of suitable acids. The compounds of the formula I and the physiologically acceptable acid-addition salts thereof are principally suitable for the prevention and treatment of inflammatory--in particular inflammatory rheumatic--disorders. Some of the intermediates formed during the preparation of the compounds of the formula I are also novel, namely 1-amino-2-mercaptoimidazole ##STR4## and 1-amino-2-thioxo-5-imidazolidinone ##STR5##