In vivo delivery of neurotransmitters by implanted, encapsulated cells
US4892538A · kind A · utility
392Cited by
8References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 17, 1987 |
| Grant date | Jan 9, 1990 |
| Priority date | — |
| Expiry date | Nov 17, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2533/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and devices are disclosed for the delivery of a neurotransmitter from an implanted, neurotransmitter-secreting cell culture to a target region in a subject. The cell culture is maintained within a biocompatible, semipermeable membrane which permits the diffusion of the neurotransmitter therethrough while excluding viruses, antibodies, and other detrimental agents present in the external environment from gaining access. Implantable cell culture devices are disclosed, some of which may be retrieved from the subject, replaced or recharged with new, neurotransmitter-secreting cell cultures, and reimplanted.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.