Antiandrogenic 17-alpha-alkyl steroids

US4892867A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Rudolf Wiechert · Berlin, DE
• Dieter Bittler · Berlin, DE
• Annerose Schleusener · Berlin, DE
• Manfred Albring · Berlin, DE

Key dates

• Filing date: Oct 14, 1986
• Grant date: Jan 9, 1990
• Expiry date: Oct 14, 2006

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

17.alpha.-Alkyl steroids of the formula ##STR1## wherein R.sub.1 is hydrogen, acyl, alkyl, alkenyl, alkyl or alkenyl interrupted by an oxygen atom, cyclopentyl, or tetrahydropyranyl, PA1 R.sub.2 is alkyl or alkenyl of 2-6 carbon atoms, PA1 X is oxygen or the grouping H(OR.sub.3) wherein R.sub.3 is hydrogen, acyl, alkyl, alkenyl, alkyl or alkenyl interrupted by an oxygen atom, cyclopentyl, or tetrahydropyranyl, upon topical application, display antiandrogenic properties and can be utilized for the treatment of acne, seborrhea, alopecia and hirsutism.