Derivatives of biliary acids, process for the production thereof and corresponding pharmaceutical compositions
US4892868A · kind A · utility
31Cited by
9References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 10, 1986 |
| Grant date | Jan 9, 1990 |
| Priority date | — |
| Expiry date | Jul 10, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J9/005
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
New derivatives of chenodeoxycholic, ursodeoxycholic, cholic and ursocholic acids, bearing a methyl group in the side chain, in an alfa position to the carboxylic group, the corresponding nor- and di-nor- derivatives, and the corresponding conjugates with taurine and glycine, are described. The compounds of the invention are prepared by methylation of the esters with methyl iodide in the presence of lithium-dialkylamides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.