Patent · US Expired

Process for the preparation of n-acetylphenylalanine

US4892971A · kind A · utility

0Cited by

7References

3Claims

0Family size

Assignee

Hoechst GmbH · DE

Inventors

Heinz Erpenbach · Cologne, DE
Klaus Gehrmann · Lechenich, DE
Peter Horstermann · Lechenich, DE

Key dates

Filing date	Oct 14, 1988
Grant date	Jan 9, 1990
Priority date	—
Expiry date	Oct 14, 2008

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C237/00
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

In the process for the preparation of N-acetylphenylalanine by opening the ring of 2-methyl-4-benzylidene-1,3-oxazolin-5-one with water to give 2-acetaminocinnamic acid and subsequently catalytically hydrogenating the latter, both reaction stages are carried out in a mixture of an aliphatic C.sub.3 -ketone to C.sub.10 -ketone or a water-miscible ether and water as the solvent, and the hydrogenation of the 2-acetaminocinnamic acid is carried out at temperatures of 10.degree. to 50.degree. C. and pressures of 1 to 15 bar in the presence of a supported palladium catalyst.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.