Solubilization of proteins for pharmaceutical compositions using polyproline conjugation
US4894226A · kind A · utility
55Cited by
7References
16Claims
0Family size
Assignee
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Key dates
| Filing date | Nov 14, 1986 |
| Grant date | Jan 16, 1990 |
| Priority date | — |
| Expiry date | Nov 14, 2006 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A pharmaceutical composition is prepared wherein a biologically active conjugated protein is dissolved in an aqueous carrier medium in the absence of a solubilizing agent. The unconjugated protein, which is not readily water-soluble at pH 6-8 without such solubilizing agent, is covalently conjugated to polyproline via a flexible spacer arm and exhibits substantial biological activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.