5-Substituted-3-aminoalkyl indole derivatives
US4894387A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 26, 1987 |
| Grant date | Jan 16, 1990 |
| Priority date | — |
| Expiry date | Mar 26, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds are disclosed of the general formula (I) ##STR1## wherein R.sub.1 represents halogen, alkyl, alkoxy or hydroxyl, or a group NR.sub.a R.sub.b or CON.sub.a R.sub.b, where R.sub.a and R.sub.b are hydrogen, alkyl or alkenyl or with the nitrogen atom form a saturated monocyclic 5 to 7-membered ring; PA1 R.sub.2 represents hydrogen or alkyl; PA1 R.sub.3 and R.sub.4 represent hydrogen, C.sub.1-3 alkyl or propenyl or R.sub.3 and R.sub.4 together form an aralkylidene group; Alk represents a C.sub.2-3 alkylene chain; PA1 n and m, are integers of 1 to 4 or n is zero, and their physiologically acceptable salts and solvates. The compounds are described as useful in treating pain originating from dilatation of the cranial vasculature in particular migraine and cluster headache and can be formulated in conventional manner as pharmaceutical compositions with carriers or excipients for administration by any convenient route.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.