Homologs of aprotinin produced from a recombinant host, process expression vector and recombinant host therefor and pharaceutical use thereof

US4894436A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Ernst-August Auerswald · Munich, DE
• Werner Schroder · Wuppertal, DE
• Eugen Schnabel · Wuppertal, DE
• Wolfgang Bruns · Wuppertal, DE
• Gerd Reinhardt · Kelkheim, DE
• Michael P. Kotick · Elkhart, US

Key dates

• Filing date: Mar 23, 1987
• Grant date: Jan 16, 1990
• Expiry date: Mar 23, 2007

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Microbially produced aprotinin and aprotinin homologs used for treating patients suffering from an excess release of pancreatic elastase, serum elastase or leukocyte elastase.