Toxin conjugates
US4894443A · kind A · utility
95Cited by
8References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 7, 1984 |
| Grant date | Jan 16, 1990 |
| Priority date | — |
| Expiry date | Sep 7, 2004 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/825
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A novel class of polypeptides of the general formula (F-(Pro).sub.n).sub.m F, wherein F represents a flexible amino acid sequence wherein each amino acid is individually selected from the group consisting of serine, glycine, and threonine, and n is an integer from 4-8 inclusive and m is an integer from 1-4 inclusive, is disclosed. Thses polypeptides are useful in the construction of conjugates between antibodies and peptide toxins. The preparation of such conjugate toxins by linking antibodies to toxin/spacer composites prepared by recombinant techniques is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.