Recovery and purification of immunogens from immunogen-alum complexes
US4894444A · kind A · utility
2Cited by
4References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 16, 1987 |
| Grant date | Jan 16, 1990 |
| Priority date | — |
| Expiry date | Jul 16, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/34
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Immunologically intact protein or peptide immunogens are recovered from vaccines consisting of immunogen-aluminum hydroxide (alum) complexes. Recovery consists of dissolution of the complexes with an alkali metal salt of a carboxylic acid at a basic pH, reduction of the pH to physiological levels, removal of excess dissolvent and isolation of the protein or peptide immunogen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.