Radioactive compositions for the treatment of calcific tumors
US4897254A · kind A · utility
32Cited by
10References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 3, 1987 |
| Grant date | Jan 30, 1990 |
| Priority date | — |
| Expiry date | Mar 3, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2121/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Certain particle-emitting radionuclides, e.g. Samarium-153, have been complexed with certain alkylenepolyaminocarboxylic acid chelants. Compositions containing these complexes have been found useful in the treatment of calcific tumors in animals. The stability constant, log K, of the useful complexes is from about 14 to about 17 and the molar ratio of chelant to radionuclide in the compositions is such that the chelant is present in an amount sufficient to inhibit uptake of the radionuclide by soft tissue.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.