Drug preparations of reduced toxicity

US4897384A · kind A · utility

Assignee

• The Liposome Company, Inc. · US

Inventors

• Andrew S. Janoff · Yardley, US
• Carl R. Alving · Bethesda, US
• Michael W. Fountain · Plainsboro, US
• Robert P. Lenk · Lambertville, US
• Marc J. Ostro · New Brunswick, US
• Mircea C. Popescu · Plainsboro, US
• Paul A. Tremblay · Princeton, US
• Alan L. Weiner · Lawrenceville, US

Key dates

• Filing date: Mar 24, 1986
• Grant date: Jan 30, 1990
• Expiry date: Mar 24, 2006

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/60
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Preparations of drugs in admixture with certain ligands are described which, when administered to animals or humans, are less toxic than conventional drug preparations. Although the toxicity of the drug-ligand preparations described is greatly reduced, the drug retains pharmacological activity.