Bis(indolyl)ethylene process

US4897494A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Hubertus Psaar · Leverkusen, DE
• Horst Berneth · Leverkusen, DE

Key dates

• Filing date: Oct 24, 1988
• Grant date: Jan 30, 1990
• Expiry date: Oct 24, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/24
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Bis(indolyl)ethylenes of the formula ##STR1## wherein R.sub.1 denotes hydrogen, alkyl, aralkyl or aryl, PA1 R.sub.2 denotes hydrogen, alkyl or aryl, PA1 R.sub.3 denotes hydrogen, alkyl, alkenyl, COOH or aryl and PA1 R.sub.4 denotes hydrogen, alkyl, alkoxy, cycloalkoxy or halogen, and these substituents, in turn, can carry non-ionic radicals or a carboxyl group, are obtained by reaction of indoles of the formula ##STR2## with carboxylic acids of the formula EQU R.sub.3 --CH.sub.2 --COOH (III) their chlorides, esters, for example alkyl esters, or anhydrides in the presence of phosphorus oxychloride.