Process for preparing optically active indoline-2-carboxylic acid
US4898822A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 31, 1986 |
| Grant date | Feb 6, 1990 |
| Priority date | — |
| Expiry date | Mar 31, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/925
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A process for preparing optically active indoline-2-carboxylic acid by an optical resolution, which comprises subjecting a racemic ester of (R,S)-indoline-2-carboxylic acid having the general formula [(R,S)-I] to the action of an enzyme or a microorganism having a stereo-selective esterase activity, which is capable of asymmetrically hydrolyzing the racemic ester [(R,S)-I] to give optically active indoline-2-carboxylic acid having the formula [II*] so as to produce the hydrolysis product, i.e. optically active indoline-2-carboxylic acid [II*] and an unreacted optically active ester of indoline-2-carboxylic acid having the general formula [I*], isolating each optically active form, and further, if necessary, hydrolyzing the obtained optically active ester [I*] to give an optical antipode of the acid [II*]. According to the process of the present invention, optically active indoline-2-carboxylic acid with a high optical purity can be prepared in a simple process with a good yield.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.