Method to solubilize tissue plasminogen activator
US4898826A · kind A · utility
8Cited by
2References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 10, 1987 |
| Grant date | Feb 6, 1990 |
| Priority date | — |
| Expiry date | Dec 10, 2007 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01D15/34
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Practical amounts of tissue plasminogen activator (tPA) whether secreted by cells naturally producing it or prepared by recombinant means can be solubilized by providing, in aqueous medium at pH 5-14 8 a solubilizing amount of a basic amino acid optionally and preferably, in the presence of a citric acid moiety. The ability to solubilize tPA at concentrations of up to 50 mg is significant as an aid in permitting smaller volumes for purification and permitting single injections of the drug as opposed to intravenous administration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.