Process for the preparation of phenylalanine n-propyl ester hydrochloride

US4898966A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Heinz Erpenbach · Cologne, DE
• Klaus Gehrmann · Lechenich, DE
• Peter Horstermann · Lechenich, DE
• Erhard Jagers · Bornheim, DE
• Georg Kohl · Hürth, DE

Key dates

• Filing date: Oct 11, 1988
• Grant date: Feb 6, 1990
• Expiry date: Oct 11, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C227/18
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

In order to prepare phenylalanine n-propyl ester hydrochloride, phenylalanine hydrochloride is reacted with n-propanol in the molar ration 1: (5 to 20) at temperatures from 80.degree. to 110.degree. C., preferably 85.degree. to 105.degree. C., at pressures from 0.1 to 1.5 bar in the presence of 0.1 to 0.75 mole of HCl/mole of phenylalanine hydrochloride as catalyst and in the presence of water entrainer, a concentration of water entrainer of 20 to 50% by weight being maintained in the reaction mixture.