Novel pharmaceutical composition containing estradiol and progesterone for oral administration
US4900734A · kind A · utility
121Cited by
6References
34Claims
0Family size
Inventors
Key dates
| Filing date | Aug 27, 1987 |
| Grant date | Feb 13, 1990 |
| Priority date | — |
| Expiry date | Aug 27, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/57
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A pharmaceutical composition is provided for oral administration. The composition comprises estradiol dissolved in an oil vehicle containing a suspension of micronized progesterone. The oil vehicle is high in glycerides of polyunsaturated fatty acids. The estradiol and micronized progesterone contained in the oil are more readily absorbable in the blood stream and achieve enhanced estradiol and progesterone blood serum levels. The pharmaceutical composition according to the invention can be readily formulated into capsules and administered for the treatment of menopausal symptoms.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.