1.4-Dihydropyridines

US4900750A · kind A · utility

Assignee

• John Wyeth & Brother Limited · GB

Inventors

• John L. Archibald
• Terence J. Ward
• Albert Opalko · Maidenhead, GB

Key dates

• Filing date: Aug 3, 1987
• Grant date: Feb 13, 1990
• Expiry date: Aug 3, 2007

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention concerns compounds of formula ##STR1## or salts thereof, wherein: Ar is an optionally substituted aryl radical; PA0 R represents hydrogen or an optionally substituted alkyl, aralkyl, or aryl group; PA0 R.sup.1 and R.sup.2 are the same or different and are selected from hydrogen and saturated or unsaturated, cyclic or acyclic aliphatic hydrocarbon residues optionally substituted by one or more groups selected from halogen, OH, carboxy, CN, alkoxy, alkylthio, aryloxy, alkoxycarbonyl, amino, substituted amino, and optionally substituted aryl; PA0 A and B independently represent a group of formula --XR.sup.3 wherein PA1 X is a group of formula --(CHR.sup.6).sub.p Y(CHR.sup.7).sub.q --wherein PA1 Y represents --O--, --S--, --NR.sup.8 -- or a direct bond; p and q each represent 0, 1 or 2 providing that p and q do not both represent O when Y is a direct bond; and R.sup.6, R.sup.7 and R.sup.8 are independently hydrogen or alkyl; and R.sup.3 is an optionally substituted nitrogen ring heteroaryl radical optionally containing other ring heteroatoms selected from oxygen, nitrogen and sulphur; which compounds possess pharmaceutical activity particularly inhibition of blood platel…