2-Pyridinyl-phenyl-sulphinyl-and-phenyl-thio-benzimidazoles having antiflammatory or gastic acid secretion inhibition activity
US4900751A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 24, 1987 |
| Grant date | Feb 13, 1990 |
| Priority date | — |
| Expiry date | Sep 24, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of formula I, ##STR1## in which A is a 5 or 6 membered, fully unsaturated, carbocyclic or heterocyclic ring, PA1 B is a 5 or 6 membered, fully unsaturated, nitrogen containing heterocyclic ring, PA1 X is NR.sub.19, O or S, PA1 R.sub.19 is hydrogen or alkyl optionally substituted by --OCOR, PA1 n is 0 or 1, PA1 R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and R.sub.10 have various significances, PA1 R.sub.1 and R.sub.2, are hydrogen or alkyl or together with the ring carbon atoms to which they are attached, form a benzene or pyridine ring, which ring carries substituents R.sub.15, R.sub.16, R.sub.17 and R.sub.18, PA1 R.sub.15, R.sub.16, R.sub.17 and R.sub.18, have various significances, with certain provisos are described. Processes for making the compounds and pharmaceutical formulations containing them, e.g. for the treatment of conditions including excess gastric acid secretion, are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.