Synthesis of podophyllotoxin derivatives
US4900814A · kind A · utility
5Cited by
3References
9Claims
0Family size
Inventors
Key dates
| Filing date | Dec 15, 1986 |
| Grant date | Feb 13, 1990 |
| Priority date | — |
| Expiry date | Dec 15, 2006 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There is provided a novel process for the production of the epipodophyllotoxin glycosides, Etoposide and Teniposide. There are further provided certain novel 4'-demethylepipodophyllotoxin derivatives of the following formula ##STR1## where W is hydrogen or 2,3-di-O-acetyl-4,6,O-ethylidene-D-glucopyran-1-yl. These intermediates are easily transformed into Etoposide and Teniposide and into further derivatives of this series.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.