Process for labelling sulfur-containing compounds
US4900830A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 28, 1987 |
| Grant date | Feb 13, 1990 |
| Priority date | — |
| Expiry date | Oct 28, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D497/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention thus provides a process for obtaining the preferential replacement by isotopes, of at least one of the hydrogen atoms selected from the group consisting of those attached to the .alpha.- or .alpha.'-carbon atoms in a compound containing the structural moiety (I) ##STR1## which comprises the steps of oxidizing the compound to the corresponding sulfoxide or sulfone which contains the corresponding structural moiety (II) ##STR2## wherein in the sulfoxide n is 1 and in the sulfone n is 2, effecting the isotopic replacement by a known method of said at least one hydrogen atom, and reducing the resultant isotope-labelled sulfoxide or sulfone to the correspondingly labelled compound containing the structural moiety (I).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.