Preparation of a polymer/interleukin-2 conjugate
US4902502A · kind A · utility
295Cited by
5References
25Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 23, 1989 |
| Grant date | Feb 20, 1990 |
| Priority date | — |
| Expiry date | Jan 23, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/60
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is a process for preparing a pharmaceutical composition comprising a biologically active conjugated protein. It comprises a polyethylene glycol or a polyoxyethylated polyol conjugated to IL-2. This protein is conjugated to reduce its immunogenicity, and increase it solubility, and increase its circulating in vivo half-life.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.