Chimeric peptides for neuropeptide delivery through the blood-brain barrier
US4902505A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Apr 25, 1988 |
| Grant date | Feb 20, 1990 |
| Priority date | — |
| Expiry date | Apr 25, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Chimeric peptides adapted for delivering neuropharmaceutical agents, such as neuropeptides into the brain by receptor-mediated transcytosis through the blood-brain barrier. The chimeric peptides include a peptide which by itself is capable of crossing the blood-brain barrier by transcytosis at a relatively high rate. The transportable peptide is conjugated to a hydrophilic neuropeptide which by itself is transportable only at a very low rate into the brain across the blood-brain barrier. The resulting chimeric peptide is transported into the brain at a much higher rate than the neuropeptide alone to thereby provide an effective means for introducing hydrophilic neuropeptides into the brain through the blood-brain barrier.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.