Novel process for the synthesis of amikacin
US4902790A · kind A · utility
9Cited by
6References
18Claims
0Family size
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Key dates
| Filing date | Oct 2, 1986 |
| Grant date | Feb 20, 1990 |
| Priority date | — |
| Expiry date | Oct 2, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A novel process for the synthesis of amikacin starting from kanamycin A protected at the positions 3 and 6' is described comprising the reaction of kanamycin A with a salt of a bivalent metal cation selected from zinc, nickel, iron, cobalt, manganese, copper and cadmium in the presence of water as the solvent or co-solvent followed by the in situ reaction of the resulting complex with a reactive derivative of L-amino-2-hydroxy-butyric acid, removal of the metal cation of the protecting groups and purification of the thus obtained raw product. The acylation under these conditions is extremely selective.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.