Multiply-tritiated steroidal-20,17-spirolactones and their use as tracer compounds

US4904462A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Paul-Eberhard Schulze
• Klaus Nickisch · Berlin, DE
• Henry Laurent
• Kunhard Pollow · Mainz, DE

Key dates

• Filing date: Apr 12, 1985
• Grant date: Feb 27, 1990
• Expiry date: Apr 12, 2005

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K51/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel, multiple-tritiated steroid-20,17-spirolactones of general Formula I ##STR1## wherein --A--B-- is --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH-- or ##STR2## and --C--D-- is ##STR3## R is hydrogen or tritium and n is 0 or 1, are usable as tracer materials for the detection of mineralocorticoid receptors.