Novel amphiphilic nucleic acid conjugates
US4904582A · kind A · utility
329Cited by
4References
19Claims
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Key dates
| Filing date | Jun 11, 1987 |
| Grant date | Feb 27, 1990 |
| Priority date | — |
| Expiry date | Jun 11, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel oligonucleotide conjugates are provided, where oligonucleotides are joined through a linking arm to a hydrophobic moiety. The resulting conjugates are more efficient in membrane transport, so as to be capable of crossing the membrane and effectively modulating a transcriptional system. In this way, the compositions can be used in vitro and in vivo, for studying cellular processes, protecting mammalian hosts from pathogens, and the like.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.