Site-specific homogeneous modification of polypeptides
US4904584A · kind A · utility
315Cited by
5References
3Claims
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Key dates
| Filing date | Dec 23, 1987 |
| Grant date | Feb 27, 1990 |
| Priority date | — |
| Expiry date | Dec 23, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A homogeneously modified protein is provided having one or more selected naturally occurring lysine residues replaced by a suitable amino acid, or having one or more lysine residues substituted for other amino acids or inserted into a polypeptide sequence, leaving selected lysine residues having .epsilon.-amino groups in the protein and coupling amine reactive compounds to selected lysine residues. Methods for producing the selected homogeneously modified proteins and pharmaceutical compositions containing such proteins are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.