Phosphorus-containing HMG-COA reductase inhibitors
US4904646A · kind A · utility
20Cited by
5References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 18, 1988 |
| Grant date | Feb 27, 1990 |
| Priority date | — |
| Expiry date | Apr 18, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/4407
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have the structure ##STR1## including salts thereof, wherein R is OH, lower alkoxy or lower alkyl; R.sup.x is H or alkyl; PA0 X is --O-- or --NH--; PA0 n is 1 or 2 PA0 Z is a hydrophobic anchor, such as ##STR2## wherein the dotted lines represent optional double bonds. New intermediates used in preparing the above compounds, pharmaceutical compositions containing such compounds and a method for using such compounds to inhibit cholesterol biosynthesis are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.