Antimicrobial pharmaceutical composition
US4904647A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 20, 1988 |
| Grant date | Feb 27, 1990 |
| Priority date | — |
| Expiry date | Jul 20, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a synergistic, antimicrobial pharmaceutical composition containing 0.01 to 50% by weight of a quinolinecarboxylic acid derivative or a naphthyridinecarboxylic acid derivative of the formula (I), ##STR1## wherein X is carbon or nitrogen; PA0 R.sup.1 is hydrogen or fluorine; PA0 R.sup.2 is methyl, piperazino or methylpiperazino group; or R.sup.1 and R.sup.2 together are a methylenedioxy group; and 0.01 to 95% by weight of a tetracycline derivative of the formula (II), ##STR2## wherein R.sup.3 and R.sup.4 are hydrogen; or PA0 R.sup.3 and R.sup.4 together represent an additional chemical bond, in 20:1 to 1:50 ratio of the compound of the formula (I) to the compound of the formula (II), optionally in an admixture with an amount required to 100% by weight of an inert, solid or liquid carrier such as magnesium carbonate, magnesium stearate, starch, talc, cyclodextrine or water and other additives such as filling, disintegrating, sliding and emulsifying agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.