Estradiol transdermal delivery system
US4906475A · kind A · utility
67Cited by
161References
8Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Feb 16, 1988 |
| Grant date | Mar 6, 1990 |
| Priority date | — |
| Expiry date | Feb 16, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/565
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to a transdermal delivery system for an active substance. The active substance is estrogen or its derivatives and preferably is 17-beta-estradiol. The system comprises an impermeable backing layer and a matrix affixed thereto. The matrix comprises, on a weight percentage basis, from about 60 to about 95% of an adhesive polymer, from about 5 to about 20% of a solvent, from about 0.2 to about 4% of a skin penetration enhancer, and from about 0.5 to about 5% of the active substance. The system is free of any discrete permeable, polymeric, diffusion-controlling membrane.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.