Method of treating posttraumatic nervous injuries with dipeptide derivatives

US4906614A · kind A · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Hubert Giertz
• Hans Barth · Aachen, DE
• Leopold Flohe · Roetgen, DE

Key dates

• Filing date: Jun 14, 1988
• Grant date: Mar 6, 1990
• Expiry date: Jun 14, 2008

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of preventing or treating posttraumatic nervous injuries by administering a compound of the formula: ##STR1## wherein R.sub.1 is hydrogen, a lower alkyl group, cyclohexyl or benzyl; Z is one of the groups ##STR2## if Z is a group (a), R.sub.2 and R.sub.3 together represent an additional bond between the carbon atoms bearing them, or if Z represents a group (b), R.sub.2 is hydrogen; R.sub.4 is hydrogen or lower alkyl; R.sub.5 is hydrogen, lower alkyl or phenyl, and R.sub.6 is hydrogen or methyl. Hydrates or pharmaceutically acceptable acid addition salts may also be used in the method. Pharmaceutical compositions used in this method containing such compounds in a prophylactically or therapeutically effective amount may be administered by infusion, injection, orally, perorally, rectally, percutaneously or other route.