Esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3-(4H)-one and related compounds
US4906755A · kind A · utility
21Cited by
3References
10Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jun 30, 1989 |
| Grant date | Mar 6, 1990 |
| Priority date | — |
| Expiry date | Jun 30, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/47
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to a group of esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(3H)-ones and related compounds. The compounds are prepared from the appropriate carboxylic acids and alcohols by standard procedures or, where steric factors are significant, a new process which makes use of heavy metal salts of super acids can be used. The compounds involved are useful in the treatment of migraine and similar disorders and in cytotoxic drug-induced vomiting.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.