Monoclonal antibodies to human kininogen and methods of preparing same
US4908431A · kind A · utility
16Cited by
0References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 22, 1986 |
| Grant date | Mar 13, 1990 |
| Priority date | — |
| Expiry date | Jan 22, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/809
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Two novel cell lines, ATCC #HB-8963 and ATCC #HB-8964 produce monoclonal antibody to human kininogen. One of the antibodies specifically recognizes the heavy chain of high and low molecular weight kininogen (the later protein is identical to alpha cysteine protease inhibitor). The other antibody recognizes the light chain of high molecular weight kininogen. The hybridomas are formed by fusing spleen cells from immunized BALB/c AnSkh mice with P3X63Ag8 or SP2/0-Ag14 myeloma cells. Diagnostic, therapeutic and biochemical uses of the monoclonal antibodies are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.