2-Hydroxy-propanoic acid acyclic alkyl esters for benzothiazepines
US4908469A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | May 18, 1988 |
| Grant date | Mar 13, 1990 |
| Priority date | — |
| Expiry date | May 18, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C323/56
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
In general, the present invention provides, in one aspect, a process comprising contacting a 2-Aminothiophenol with an optically active 3-(4-alkyloxyphenyl)glycidic acid acyclic alkyl ester by step(s) under conditions such that an optically active 2-hydroxy-3-(4-alkyloxyphenyl)-3-(2-Aminophenylthio)propionic acid acyclic alkyl ester is prepared. Another aspect comprises the optically active 2-hydroxy-3-(4-alkyloxyphenyl)-3-(2-Aminophenylthio)propionic acid acyclic alkyl ester. A preferred aspect is a process comprising contacting 2-aminothiophenol per se with a 3-(4-methoxyphenyl)glycidic acid methyl ester by step(s) under conditions such that a 2-hydroxy-3-(4-methoxyphenyl)-3-(2-aminophenylthio)propionic acid methyl ester is prepared.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.