Intermediates for preparing 1,6-dicarba-vasopressin compounds
US4908475A · kind A · utility
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Key dates
| Filing date | May 9, 1988 |
| Grant date | Mar 13, 1990 |
| Priority date | — |
| Expiry date | May 9, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
New compounds which have potent V.sub.2 -vasopressin antagonistic activity are prepared by a 1,6-cyclization using peptide bond formation. The structures of the compounds are characterized by a Pas.sup.1,6 or Tas.sup.1,6 cyclized unit. Also a chiral synthesis of the optically pure Pas intermediates is described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.