Method for attaining in vivo tissue-specific contrast by nuclear magnetic resonance imaging

US4909257A · kind A · utility

Assignee

• The Regents of the University of California · US

Inventors

• Barry L. Engelstad · Orinda, US
• Robert C. Brasch · Mill Valley, US
• Robert S. Hattner · Mill Valley, US
• George Wesbey · Del Mar, US
• John P. Huberty · Corte Madera, US

Key dates

• Filing date: Apr 28, 1989
• Grant date: Mar 20, 1990
• Expiry date: Apr 28, 2009

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/24
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method is provided for obtaining in vivo diferentiation of tissues in an animal by nuclear magnetic resonance imaging comprising the steps of introducing into the animal a complex comprising a paramagnetic ferric ion and a chelator. Particular contrast agents, Fe(HBED) and Fe(EHPG), are excretable by a hepatobiliary pathway.