Method of inhibiting leukotriene biosynthesis by oral administration of p-aminophenols or derivatives thereof
US4910208A · kind A · utility
5Cited by
8References
22Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Feb 19, 1988 |
| Grant date | Mar 20, 1990 |
| Priority date | — |
| Expiry date | Feb 19, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D215/38
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method is provided for inhibiting leukotriene biosynthesis and thus treating asthma, psoriasis or inflammation by oral administration of p-aminophenols having the structure ##STR1## wherein m is 0 to 5; X is CH or N; R.sup.1 and R.sup.2 may be the same or different and are H, lower alkyl, aryl, hydroxy, hydroxyalkyleneoxy, alkylthio, alkoxy, alkanoyloxy, aryloxy, halo, carboxy, alkoxycarbonyl or amido; R.sup.3 is H, lower alkyl, alkanoyl or aroyl; and R.sup.4 is H, lower alkyl, benzoyl or alkanoyl, and including acid-addition salts thereof, with the proviso that when R.sup.4 is benzoyl, R.sup.2 is other than H.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.