Rapid differentiation of bacteria using cyclic polypeptide antibiotics
US4912036A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 24, 1986 |
| Grant date | Mar 27, 1990 |
| Priority date | — |
| Expiry date | Sep 24, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/873
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Rapid differentiation between viable gram-positive and gram-negative bacteria is accomplished with certain polypeptide antibiotics which are used in combination with a compound which is normally reducible by the bacteria. The antibiotics selectively inhibit the reduction of the reducible compound by gram-positive bacteria but do not substantially affect the reducing capacity of the gram-negative bacteria. The particular antibiotics useful are cyclic polypeptides which affect the function of the cytoplasmic membrane of bacteria. A particular polypeptide antibiotic, polymixin B, will distinguish Proteus bacteria from other gram-negative genera.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.