Process for the preparation of 3-cyano-4-aryl-pyrroles
US4912229A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | May 19, 1988 |
| Grant date | Mar 27, 1990 |
| Priority date | — |
| Expiry date | May 19, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D207/34
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the preparation of a 3-cyano-4-aryl-pyrrole of the formula ##STR1## in which Ar is optionally substituted heteroaryl or aryl, which comprises (a) reacting an .alpha.-cyanoacrylic acid derivative of the formula ##STR2## in which R.sup.1 is amino or alkoxy, with an isocyanoacetic acid ester of the formula ##STR3## in which R.sup.2 is alkyl, in the presence of a base thereby to produce a .DELTA..sup.2 -pyrroline-2-carboxylic acid derivative of the formula ##STR4## in which X represents hydrogen or an equivalent of an inorganic or organic cation, and (b) oxidatively decarboxylating the .DELTA..sup.2 -pyrroline-2-carboxylic acid. The end products are known fungicides and the intermediates IVa are new and themselves fungicidally active.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.