Process for preparing (trans)-4-phenyl-L-proline derivatives
US4912231A · kind A · utility
5Cited by
2References
17Claims
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Inventors
Key dates
| Filing date | Jun 17, 1988 |
| Grant date | Mar 27, 1990 |
| Priority date | — |
| Expiry date | Jun 17, 2008 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process is provided for preparing (trans)-4-phenyl-L-proline derivatives with excellent stereospecificity, which are useful in preparing certain ACE inhibitors, which process involves reacting a proline derivative of the structure ##STR1## whereing R is a nitrogen protecting group, R.sub.1 is H, aryl, arylalkyl or lower alkyl, and X is a leaving group such as fluorine, an alkyl sulfonate, arylsulfonate or cycloalkyl sulfonate is reacted with an aromatic nucleophile, such as benzene, in the presence of a Lewis acid such as AlCl.sub.3 to form the (trans)-4-phenyl-L-proline derivative of the structure ##STR2##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.