Anthracycline derivatives having cytostatic activity

US4914191A · kind A · utility

Assignee

• Behringwerke Aktiengesellschaft · DE

Inventors

• Peter Hermentin · Marburg, DE
• Michael Paal · Hamburg, DE
• Cenek Kolar · Marburg, DE
• Hans Kraemer · Marburg, DE
• Dieter Hoffmann · Marburg, DE
• Hans G. Berscheid · Schwalbach am Taunus, DE
• Dirk Bottger · Liederbach, DE

Key dates

• Filing date: Jul 7, 1988
• Grant date: Apr 3, 1990
• Expiry date: Jul 7, 2008

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to new anthracycline derivatives having cytostatic activity and the general formula I ##STR1## in which the radicals R.sup.1 is hydrogen or a hydroxyl group, R.sup.2 is hydrogen or a hydroxyl group or a structure of the formula II, and R.sup.3 is a hydroxyl group or a structure of the formula II ##STR2## in which R.sup.4 is an aliphatic or aromatic acyl group, with the proviso that at least one of the radicals R.sup.2 and R.sup.3 has a structure of the formula II, which are optionally in the form of a salt of an inorganic or organic acid, as well as to the process for the preparation thereof, and to the use thereof in pharmaceuticals.