3'-Azido-2',3'-dideoxyuridine anti-retroviral composition
US4916122A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Oct 2, 1987 |
| Grant date | Apr 10, 1990 |
| Priority date | — |
| Expiry date | Oct 2, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions for the treatment of AIDS and ARC having the following compound as an active ingredient: ##STR1## where R.sup.1 is OH, monophosphate, diphosphate, or triphosphate; or a pharmacologically acceptable salt thereof. The primary advantage of this compound is its highly selective anti-retroviral activity, i.e., it significantly decreases viral replication as measured as reverse transcriptase activity while demonstrating orders of magnitude less cytotoxicity than other anti-viral compounds such as AZT. In a preferred embodiment, the compound is present in an amount sufficient to inhibit the HIV reverse transcriptase activity but not significantly inhibit human DNA polymerase activity. Also included within the scope of this invention are 3'-azido-2',3'-dideoxyuridine mono-, di-, and triphosphate and compositions containing these compounds as the active agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.