Thiadiazinones

US4916128A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Rochus Jonas · Darmstadt, DE
• Jaime Piulats · Barcelona, ES
• Michael Klockow · Lutherstadt Eisleben, DE
• Ingeborg Lues · Darmstadt, DE
• Hans-Jochen Schliep · Traisa, DE

Key dates

• Filing date: Jun 6, 1988
• Grant date: Apr 10, 1990
• Expiry date: Jun 6, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Thiadiazinones of the formula I ##STR1## wherein A is --CHR.sup.4 --CHR.sup.5 --, --CH.sub.2 --CR.sup.4 R.sup.5 --, --CR.sup.4 R.sup.5 --CH.sub.2 --, --CHR.sup.4 --CHR.sup.5 --CH.sub.2 --, --CHR.sup.4 --CH.sub.2 --CHR.sup.5 --, --CH.sub.2 --CHR.sup.4 --CHR.sup.5 --, --CR.sup.4 R.sup.5 --CH.sub.2 CH.sub.2 --, --CH.sub.2 --CR.sup.4 R.sup.5 --CH.sub.2 -- or --CH.sub.2 CH.sub.2 --CR.sup.4 R.sup.5 --, PA1 R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are each independently H, C.sub.1-5 -alkyl, C.sub.2-5 -alkenyl or C.sub.2-5 -alkinyl, PA1 R.sup.3 is also C.sub.1-15 -acyl, PA1 R.sup.6 is H, alkyl, alkoxyl, OH, F, Cl, Br or I and PA1 Z is (H, H), (H, alkyl), (alkyl, alkyl) or O, the alkyl, alkenyl, alkinyl and/or alkoxy groups in each case containing up to 5 C atoms, but wherein, if A is --CH.sub.2 CH.sub.2 -- and Z is O, one of the radicals R.sup.1, R.sup.2, R.sup.3 and R.sup.6 must be other than H, and salts thereof demonstrate positive inotropic action and are suitable for combating cardiovascular diseases.